This is an internal version that might contain incomplete information.

Design of Biotechnical Process and Production Systems, Project Course, 6 credits

Projektkurs i design av biotekniska process- och produktionssystem, 6 hp

TFTB32

Course starting semester

The course is disused. Offered for the last time Spring semester 2023. Replaced by TFTB52.

Main field of study

Engineering Biology

Course level

Second cycle

Course type

Programme course

Examiner

Gunnar Hörnsten

Director of studies or equivalent

Magnus Boman

Education components

Preliminary scheduled hours: 44 h
Recommended self-study hours: 116 h

Possible deviation from course syllabus/programme syllabus

ECV = Elective / Compulsory / Voluntary

Course offered for		Semester	Period	Timetable module	Language	Campus	ECV
6CKEB	Chemical Biology (Industrial Biotechnology and Production)	8 (Spring 2017)	1, 2	1, 1	Swedish	Linköping, Valla	C
6CTBI	Engineering Biology, M Sc in Engineering (Industrial Biotechnology and Production)	8 (Spring 2017)	1, 2	1, 1	Swedish	Linköping, Valla	C

Main field of study

Engineering Biology

Course level

Second cycle

Advancement level

A1X

Course offered for

Chemical Biology
Engineering Biology, M Sc in Engineering

Entry requirements

Note: Admission requirements for non-programme students usually also include admission requirements for the programme and threshold requirements for progression within the programme, or corresponding.

Prerequisites

Industrial biotechnology course is a prerequisite. It is also a prerequisite to attend the following courses that are given in parallel with the course; Biotechnical production systems; Biotechnology manufacturing; Pharmaceutical Development; Quality Management.

Intended learning outcomes

Project course accomplishing engineering skills in analysis and design of industrial bioprocesses in evaluating production and process economical prerequisites. Understand how to use common process design tools.

Course content

Follows the specified assignment to the group. This may include total production systems. Raw material supply. Just-in-time principles. Quality systems. Reaction engineering. Unit operations up- and downstream. Process modelling and use of biomechatronic methodology. Process economical evaluation. In-process analysis aspects. Total Quality Management and Process analytical technology (PAT). Process validation.

The design shall contain at detailed description of the product and its production. Calculations and modelling of the process operations are a necessity in presenting how the process will behave when implemented. The volumes, batches, yields, material flows and operations shall be presented and scheduled. Process descriptions are presented in flow schedules “hour by hour”. Estimations are presented in diagrams and tables.

Economy and resources: The chosen process is calculated based on mass balances, raw materials, operations, investments, personnel etc. The calculations are used to present the financial framework of the process/production over the complete intended time span of the production. Estimations should be presented and explained in tables/diagrams and commented in general text.

Quality management: The needs for quality assessments and controls are presented in reference to the technical and regulatory demands that are integral to the production of the product category.

Teaching and working methods

The students should in groups of 4-5 persons implement the knowledge presented in the courses on Industrial biotechnology, Biotechnical production systems; Biotechnology manufacturing; Biotechnology and Pharmaceuticals; Quality Management and Engineering. The framework is a project assignment based on industrial design issues within biotech industry. The project model CDIO (Conceive, Design, Implement and Operate) is used. The assignments resemble the work performed by industrial consultancy teams to their customers or at R&D departments of large companies. The projects contain two phases, the first centers in on the conception of the aims and means for the design and the second on development of a process for production. The latter is referred to as the design phase intended to describe the process/production as it is implemented and operated.

The course runs over the entire spring semester.
CDIO principles are applied (especially planning, develop, implementing and testing of process solutions). Project groups (4-5 members) are organized and a specified engineering design assigment is allotted to each group which requires the development of group activities based on the curricula in parallel courses.

The course runs over the entire spring semester.

Please note that the courses TMMT03 and TFTB39 should be taken during the same semester as TFTB32.

Examination

PRA1

Project

6 credits

U, G

Grades are given as ’Fail’ or ’Pass.

Grades

Two-grade scale, U, G

Other information

Course language is Swedish and the bulk of the literature is in English.

Department

Institutionen för fysik, kemi och biologi

Director of Studies or equivalent

Magnus Boman

Examiner

Gunnar Hörnsten

Education components

Preliminary scheduled hours: 44 h
Recommended self-study hours: 116 h

Course literature

Litteratur, checklistor mm från kurserna: Industriell bioteknik, Biotekniska produktionssystem , Bioteknisk tillverkningsteknik, Bioteknik och läkemedel, Offensiv kvalitetsutveckling. Litteratur från egna datasökningar mm i anslutning till projektuppdraget. Referenslitteratur till CDIO-projektet Biomechatronic Design in Biotechnology. Carl-Fredrik Mandenius och Mats Björkman. Wiley 2011. Basic Biotechnology. Colin Ratledge and Björn Kristiansen. 3d edition. Cambridge University Press 2006. Bioseparations Science and Engineering. Second Edition. Roger G. Harrison, Paul W. Todd, Scott R. Rudge, and Demetri P. Petrides. Oxford University Press 2015. In English: Literature from the following courses: Industrial biotechnology, Biotechnical production systems, Biotechnology manufacturing, Biotechnology and Pharmaceuticals, and Quality Management and Engineering Literature acquired through Searches in databases is essential in the development of the projects. Reference literature; Biomechatronic Design in Biotechnology. Carl-Fredrik Mandenius and Mats Björkman. Wiley 2011. Basic Biotechnology. Colin Ratledge and Björn Kristiansen. 3d edition. Cambridge University Press 2006. Bioseparations Science and Engineering. Second Edition. Roger G. Harrison, Paul W. Todd, Scott R. Rudge, and Demetri P. Petrides. Oxford University Press 2015.

Code	Name	Scope	Grading scale
PRA1	Project	6 credits	U, G

Grades are given as ’Fail’ or ’Pass.

Regulations (apply to LiU in its entirety)

The university is a government agency whose operations are regulated by legislation and ordinances, which include the Higher Education Act and the Higher Education Ordinance. In addition to legislation and ordinances, operations are subject to several policy documents. The Linköping University rule book collects currently valid decisions of a regulatory nature taken by the university board, the vice-chancellor and faculty/department boards.

LiU’s rule book for education at first-cycle and second-cycle levels is available at http://styrdokument.liu.se/Regelsamling/Innehall/Utbildning_pa_grund-_och_avancerad_niva.

Student rights and obligations (login required)
Linköping University common rules and regulations (in Swedish)

Course literature is preliminary.

Download

Download course literature list as PDF

Note: The course matrix might contain more information in Swedish.

I = Introduce, U = Teach, A = Utilize

		U	A
1. DISCIPLINARY KNOWLEDGE AND REASONING
	1.1 Knowledge of underlying mathematics and science (G1X level)		X
	1.2 Fundamental engineering knowledge (G1X level)		X
	1.3 Further knowledge, methods, and tools in one or several subjects in engineering or natural science (G2X level)	X	X
	1.4 Advanced knowledge, methods, and tools in one or several subjects in engineering or natural sciences (A1X level)
	1.5 Insight into current research and development work
2. PERSONAL AND PROFESSIONAL SKILLS AND ATTRIBUTES
	2.1 Analytical reasoning and problem solving	X	X
	2.2 Experimentation, investigation, and knowledge discovery
	2.3 System thinking	X	X
	2.4 Attitudes, thought, and learning		X
	2.5 Ethics, equity, and other responsibilities	X	X
3. INTERPERSONAL SKILLS: TEAMWORK AND COMMUNICATION
	3.1 Teamwork	X	X
	3.2 Communications	X	X
	3.3 Communication in foreign languages
4. CONCEIVING, DESIGNING, IMPLEMENTING AND OPERATING SYSTEMS IN THE ENTERPRISE, SOCIETAL AND ENVIRONMENTAL CONTEXT
	4.1 External, societal, and environmental context
	4.2 Enterprise and business context	X	X
	4.3 Conceiving, system engineering and management	X	X
	4.4 Designing	X	X
	4.5 Implementing	X	X
	4.6 Operating	X	X
5. PLANNING, EXECUTION AND PRESENTATION OF RESEARCH DEVELOPMENT PROJECTS WITH RESPECT TO SCIENTIFIC AND SOCIETAL NEEDS AND REQUIREMENTS
	5.1 Societal conditions, including economic, social, and ecological aspects of sustainable development for knowledge development
	5.2 Economic conditions for knowledge development
	5.3 Identification of needs, structuring and planning of research or development projects
	5.4 Execution of research or development projects
	5.5 Presentation and evaluation of research or development projects

This tab contains public material from the course room in Lisam. The information published here is not legally binding, such material can be found under the other tabs on this page.

There are no files available for this course.