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Biosensor Technology, 6 credits
Biosensorteknik, 6 hp
TFTB34
Main field of study
Engineering Biology Biomedical EngineeringCourse level
Second cycleCourse type
Programme courseExaminer
Wing Cheung MakDirector of studies or equivalent
Magnus BomanEducation components
Preliminary scheduled hours: 56 hRecommended self-study hours: 104 h
Available for exchange students
YesECV = Elective / Compulsory / Voluntary
| Course offered for | Semester | Period | Timetable module | Language | Campus | ECV | |
|---|---|---|---|---|---|---|---|
| 6CMED | 8 (Spring 2017) | 1 | 2 | English | Linköping, Valla | E | |
| 6CMED | (Biomedical Materials) | 8 (Spring 2017) | 1 | 2 | English | Linköping, Valla | E |
| 6CKEB | Chemical Biology (Protein Science and Technology) | 8 (Spring 2017) | 1 | 2 | English | Linköping, Valla | C |
| 6CTBI | Engineering Biology, M Sc in Engineering (Devices and Materials in Biomedicine) | 8 (Spring 2017) | 1 | 2 | English | Linköping, Valla | C |
Main field of study
Engineering Biology, Biomedical EngineeringCourse level
Second cycleAdvancement level
A1XCourse offered for
- Chemical Biology
- Engineering Biology, M Sc in Engineering
Entry requirements
Note: Admission requirements for non-programme students usually also include admission requirements for the programme and threshold requirements for progression within the programme, or corresponding.
Prerequisites
Molecular and surface physics (can be taken in parallel), Biochemistry, Microbiology with immunologyIntended learning outcomes
The course will give insights into the complexities involved in combining biological materials such as enzymes, antibodies and DNA with optical, electrochemical and other transducers to provide practical and easy-to-use systems. In order to integrate this knowledge and to introduce the importance of intellectual property protection, students will participate in practical classes and a group project on patent litigation at the end of the course.
The overall purpose of the course is to give the student a thorough understanding of the fundamentals and applications of biosensor technology together with an appreciation of its current and future impact on society.
Following the course, the student should be able to:
- design and construct a simple biosensor,
- use biosensors in the laboratory
- explain how biosensors are constructed and manufactured
- show how biosensors can be used to solve real analytical problems
- reflect on the patenting and commercialisation of a biosensor
Course content
This course will provide a concise overview of biosensor technology and its application in healthcare, food safety, environmental monitoring and security. The lectures and practical exercises will focus on the construction, design and manufacture of biosensors, the principal and emerging materials and components used and three case studies of key devices. Lectures and a group project will examine some pivotal biosensor patents and an example of patent litigation. The course will conclude with a consideration of commercialisation routes, ethical issues and future perspectives.
Practical exercises will focus on enzyme electrodes, bioaffinity monitoring using two examples including the BIAcore and a site visit to see the printing facilities for biosensor production in Norrköping. The group project will study a patent litigation case and will culminate in a mock court battle.
The course will cover, an introduction to biosensors, applications of biosensors, transducers and sensor systems, bioreceptors and their immobilisation, synthetic receptors and nanomaterials for biosensors, design parameters for catalytic biosensors, design of affinity biosensors, microfluidics and arrays, glucose biosensors for diabetes, surface plasmon resonance for bioaffinity monitoring, electronic noses and tongues, patenting and litigation in the field of biosensors, commercialising biosensors, ethics and future prospects.
Teaching and working methods
Lectures, practical exercises and a group assignment.
Examination
| LAB1 | Laboratory work | 1 credits | U, G |
| UPG1 | Project assignment | 1 credits | U, G |
| TEN2 | Oral or written examination | 4 credits | U, 3, 4, 5 |
The written examination will test the ability of the student to understand different biosensor technologies and concepts together with their practical application and commercialisation. During the practical laboratory exercises the student will be expected to construct and use enzyme electrodes for glucose measurement and to learn how to operate the BiaCore system for bioaffinity monitoring. The site visit will be used to assess observation skills and inquisitiveness. The group project will test the student’s ability to work as part of a team to analyse a specific biosensor technology in detail, to present technical and commercial arguments and to individually reflect on the outcome.
Grades
Four-grade scale, LiU, U, 3, 4, 5Department
Institutionen för fysik, kemi och biologiDirector of Studies or equivalent
Magnus BomanExaminer
Wing Cheung MakCourse website and other links
http://www.ifm.liu.se/edu/coursescms/tftb34Education components
Preliminary scheduled hours: 56 hRecommended self-study hours: 104 h
Course literature
YouTube Video: Biosensors: An Introduction by Anthony Turner: http://www.youtube.com/watch?v=KChAkSAizCw Turner, A.P.F. (2013). Biosensors: sense and sensibility. Chemical Society Reviews 42 (8), 3184-3196. OPEN ACCESS: http://xlink.rsc.org/?doi=C3CS35528D Newman, J.D. and Turner, A.P.F. (2005). Home blood glucose biosensors: a commercial perspective. Biosensors and Bioelectronics 20, 2435-2453. (available online in LiU) Handbook of Biosensors and Biochips; Robert S. Marks, Christopher R. Lowe, David C. Cullen, Howard H. Weetall, Isao Karube, (2007) Wiley (available as e-book in LiU) Chemical sensors and biosensors; Brian R. Eggins (2002) Wiley (available in LiU library) US Patent: 5,436,161 - Matrix coating for sensing surfaces capable of selective biomolecular interactions, to be used in biosensor systems. Biacore AB.: http://www.google.com/patents/US5436161?dq=Patent+US+5,436,161&hl=en&sa=X&ei=HSf5UZjuLYLPtAbzm4GQDg&ved=0CDQQ6AEwAA Reviews and articles in the Elsevier journal Biosensors and Bioelectronics (available online in LiU): www.elsevier.com/locate/bios Biosensors and Bioelectronics Centre website: www.ifm.liu.se/biosensors PDF files of lectures and accompanying material.| Code | Name | Scope | Grading scale |
|---|---|---|---|
| LAB1 | Laboratory work | 1 credits | U, G |
| UPG1 | Project assignment | 1 credits | U, G |
| TEN2 | Oral or written examination | 4 credits | U, 3, 4, 5 |
The written examination will test the ability of the student to understand different biosensor technologies and concepts together with their practical application and commercialisation. During the practical laboratory exercises the student will be expected to construct and use enzyme electrodes for glucose measurement and to learn how to operate the BiaCore system for bioaffinity monitoring. The site visit will be used to assess observation skills and inquisitiveness. The group project will test the student’s ability to work as part of a team to analyse a specific biosensor technology in detail, to present technical and commercial arguments and to individually reflect on the outcome.
Regulations (apply to LiU in its entirety)
The university is a government agency whose operations are regulated by legislation and ordinances, which include the Higher Education Act and the Higher Education Ordinance. In addition to legislation and ordinances, operations are subject to several policy documents. The Linköping University rule book collects currently valid decisions of a regulatory nature taken by the university board, the vice-chancellor and faculty/department boards.
LiU’s rule book for education at first-cycle and second-cycle levels is available at http://styrdokument.liu.se/Regelsamling/Innehall/Utbildning_pa_grund-_och_avancerad_niva.
Course literature is preliminary.
YouTube Video: Biosensors: An Introduction by Anthony Turner: http://www.youtube.com/watch?v=KChAkSAizCw
Turner, A.P.F. (2013). Biosensors: sense and sensibility. Chemical Society Reviews 42 (8), 3184-3196. OPEN ACCESS: http://xlink.rsc.org/?doi=C3CS35528D
Newman, J.D. and Turner, A.P.F. (2005). Home blood glucose biosensors: a commercial perspective. Biosensors and Bioelectronics 20, 2435-2453. (available online in LiU)
Handbook of Biosensors and Biochips; Robert S. Marks, Christopher R. Lowe, David C. Cullen, Howard H. Weetall, Isao Karube, (2007) Wiley (available as e-book in LiU)
Chemical sensors and biosensors; Brian R. Eggins (2002) Wiley (available in LiU library)
US Patent: 5,436,161 - Matrix coating for sensing surfaces capable of selective biomolecular interactions, to be used in biosensor systems. Biacore AB.: http://www.google.com/patents/US5436161?dq=Patent+US+5,436,161&hl=en&sa=X&ei=HSf5UZjuLYLPtAbzm4GQDg&ved=0CDQQ6AEwAA
Reviews and articles in the Elsevier journal Biosensors and Bioelectronics (available online in LiU): www.elsevier.com/locate/bios
Biosensors and Bioelectronics Centre website: www.ifm.liu.se/biosensors
PDF files of lectures and accompanying material.
Note: The course matrix might contain more information in Swedish.
I = Introduce, U = Teach, A = Utilize
| I | U | A | Modules | Comment | ||
|---|---|---|---|---|---|---|
| 1. DISCIPLINARY KNOWLEDGE AND REASONING | ||||||
| 1.1 Knowledge of underlying mathematics and science (G1X level) |
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X
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| 1.2 Fundamental engineering knowledge (G1X level) |
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X
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| 1.3 Further knowledge, methods, and tools in one or several subjects in engineering or natural science (G2X level) |
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X
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| 1.4 Advanced knowledge, methods, and tools in one or several subjects in engineering or natural sciences (A1X level) |
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| 1.5 Insight into current research and development work |
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| 2. PERSONAL AND PROFESSIONAL SKILLS AND ATTRIBUTES | ||||||
| 2.1 Analytical reasoning and problem solving |
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X
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| 2.2 Experimentation, investigation, and knowledge discovery |
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X
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| 2.3 System thinking |
X
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| 2.4 Attitudes, thought, and learning |
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X
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| 2.5 Ethics, equity, and other responsibilities |
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| 3. INTERPERSONAL SKILLS: TEAMWORK AND COMMUNICATION | ||||||
| 3.1 Teamwork |
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X
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| 3.2 Communications |
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X
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| 3.3 Communication in foreign languages |
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X
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| 4. CONCEIVING, DESIGNING, IMPLEMENTING AND OPERATING SYSTEMS IN THE ENTERPRISE, SOCIETAL AND ENVIRONMENTAL CONTEXT | ||||||
| 4.1 External, societal, and environmental context |
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| 4.2 Enterprise and business context |
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X
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| 4.3 Conceiving, system engineering and management |
X
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| 4.4 Designing |
X
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| 4.5 Implementing |
X
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| 4.6 Operating |
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| 5. PLANNING, EXECUTION AND PRESENTATION OF RESEARCH DEVELOPMENT PROJECTS WITH RESPECT TO SCIENTIFIC AND SOCIETAL NEEDS AND REQUIREMENTS | ||||||
| 5.1 Societal conditions, including economic, social, and ecological aspects of sustainable development for knowledge development |
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| 5.2 Economic conditions for knowledge development |
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| 5.3 Identification of needs, structuring and planning of research or development projects |
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| 5.4 Execution of research or development projects |
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| 5.5 Presentation and evaluation of research or development projects |
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