Molecular Physiology and Cell Signaling Mechanisms, 6 credits

Molekylärfysiologi och cellsignaleringsmekanismer, 6 hp

NBID64

Course starting semester

The course is disused. Offered for the last time Spring semester 2024.

Main field of study

Biology Chemical Biology

Course level

Second cycle

Course type

Programme course

Examiner

Jordi Altimiras

Director of studies or equivalent

Agneta Johansson

Education components

Preliminary scheduled hours: 48 h
Recommended self-study hours: 112 h

Available for exchange students

Yes

Possible deviation from course syllabus/programme syllabus

ECV = Elective / Compulsory / Voluntary

Course offered for		Semester	Period	Timetable module	Language	Campus	ECV
6KBIO		6 (Spring 2017)	1	2	English	Linköping, Valla	E
6CKEB	Chemical Biology (Protein Science and Technology)	8 (Spring 2017)	1	2	English	Linköping, Valla	E
6MPRO	Protein Science, Master's programme (Internal)	2 (Spring 2017)	1	2	English	Linköping, Valla	C

Main field of study

Biology, Chemical Biology

Course level

Second cycle

Advancement level

A1N

Course offered for

Chemical Biology
Protein Science, Master's programme

Entry requirements

Note: Admission requirements for non-programme students usually also include admission requirements for the programme and threshold requirements for progression within the programme, or corresponding.

Prerequisites

120 ECTS including 90 ECTS in biology and a course in Molecular Genetics.

Intended learning outcomes

The student will increase her/his understanding of the role of selected molecules on the function of the human body by focusing on the relationship between molecular structure and intracellular function.
The student will develop a proficiency in finding, evaluating and compiling primary and secondary research literature on a specific topic.
The student will improve her/his skills in summarizing and communicating the results of her/his own experimental results and those of others in both written and oral form.

Course content

The course is centered around different molecules or families of molecules that are relevant to the function of the human body and also its pathology, namely:

Erythropoietin and nitric oxide involved in oxygen transport and vascular regulation
Voltage gated potassium channels involved in neuronal and cardiac excitability and associated to long QT syndrome and sudden death
Voltage gated calcium channels and calcium pumps (ryanodine receptor and sarcoplasmic reticulum calcium ATPase) involved in muscle contraction and relaxation and associated to malignant hyperthermia
G-protein coupled receptors, with special emphasis on beta-adrenergic receptors and angiotensin receptors. Involved in cardiovascular regulation and fluid homeostasis
Epithelial sodium channels, involved in cardiorenal regulation
Transient-receptor potential channels (TRP) involved in sensory transduction of temperature, pain and mechanical stimulus

Teaching and working methods

The course is composed by formal lectures, laboratory exercises and seminars , each with its own evaluation scheme. The lectures are based on primary research articles and reviews of which the most relevant ones (between 1-3 per 2h lecture) will be provided as study material. All lectures will be available to the students through Blackboard, the Learning Management System used at Linköping universitet. The laboratory exercises are linked to some of the lectures and require the writing of a lab report using quantitative methods. Attendance to the labs is compulsory. The seminars deal with generic aspects in modern biomedical research namely the use of model species and the need to balance reductionistic studies with systems biology approaches. The seminars require the discussion in smaller groups of scientific articles related with the topics.

Examination

UPG2	Report of laboratory exercises	3 credits	U, 3, 4, 5
UPG1	Seminar attendance and discussion	1 credits	U, 3, 4, 5
TEN1	Written examination	2 credits	U, 3, 4, 5

The final grade is a combination of all grades where TEN1 counts for 40 %, UPG3 10% and UPG5 50%.

Grades

Four-grade scale, LiU, U, 3, 4, 5

Department

Institutionen för fysik, kemi och biologi

Director of Studies or equivalent

Agneta Johansson

Examiner

Jordi Altimiras

Course website and other links

Education components

Preliminary scheduled hours: 48 h
Recommended self-study hours: 112 h

Course literature

Som rekommenderad kursbok,föreslås följande: Boron, W. F. & Boulpaev, E. L. Medical Physiology. A cellular and molecular approach 2nd edition (Saunders, Elsevier Science, Philadelphia, 2008).

Code	Name	Scope	Grading scale
UPG2	Report of laboratory exercises	3 credits	U, 3, 4, 5
UPG1	Seminar attendance and discussion	1 credits	U, 3, 4, 5
TEN1	Written examination	2 credits	U, 3, 4, 5

The final grade is a combination of all grades where TEN1 counts for 40 %, UPG3 10% and UPG5 50%.

Regulations (apply to LiU in its entirety)

The university is a government agency whose operations are regulated by legislation and ordinances, which include the Higher Education Act and the Higher Education Ordinance. In addition to legislation and ordinances, operations are subject to several policy documents. The Linköping University rule book collects currently valid decisions of a regulatory nature taken by the university board, the vice-chancellor and faculty/department boards.

LiU’s rule book for education at first-cycle and second-cycle levels is available at http://styrdokument.liu.se/Regelsamling/Innehall/Utbildning_pa_grund-_och_avancerad_niva.

Student rights and obligations (login required)
Linköping University common rules and regulations (in Swedish)

Course literature is preliminary.

Som rekommenderad kursbok,föreslås följande: Boron, W. F. & Boulpaev, E. L. Medical Physiology. A cellular and molecular approach 2nd edition (Saunders, Elsevier Science, Philadelphia, 2008).

Download

Download course literature list as PDF

Note: The course matrix might contain more information in Swedish.

I = Introduce, U = Teach, A = Utilize

		I	U	A	Modules	Comment
1. DISCIPLINARY KNOWLEDGE AND REASONING
	1.1 Knowledge of underlying mathematics and science (G1X level)
	1.2 Fundamental engineering knowledge (G1X level)
	1.3 Further knowledge, methods, and tools in one or several subjects in engineering or natural science (G2X level)
	1.4 Advanced knowledge, methods, and tools in one or several subjects in engineering or natural sciences (A1X level)
	1.5 Insight into current research and development work
2. PERSONAL AND PROFESSIONAL SKILLS AND ATTRIBUTES
	2.1 Analytical reasoning and problem solving
	2.2 Experimentation, investigation, and knowledge discovery
	2.3 System thinking
	2.4 Attitudes, thought, and learning
	2.5 Ethics, equity, and other responsibilities
3. INTERPERSONAL SKILLS: TEAMWORK AND COMMUNICATION
	3.1 Teamwork
	3.2 Communications
	3.3 Communication in foreign languages
4. CONCEIVING, DESIGNING, IMPLEMENTING AND OPERATING SYSTEMS IN THE ENTERPRISE, SOCIETAL AND ENVIRONMENTAL CONTEXT
	4.1 External, societal, and environmental context
	4.2 Enterprise and business context
	4.3 Conceiving, system engineering and management
	4.4 Designing
	4.5 Implementing
	4.6 Operating
5. PLANNING, EXECUTION AND PRESENTATION OF RESEARCH DEVELOPMENT PROJECTS WITH RESPECT TO SCIENTIFIC AND SOCIETAL NEEDS AND REQUIREMENTS
	5.1 Societal conditions, including economic, social, and ecological aspects of sustainable development for knowledge development
	5.2 Economic conditions for knowledge development
	5.3 Identification of needs, structuring and planning of research or development projects
	5.4 Execution of research or development projects
	5.5 Presentation and evaluation of research or development projects

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