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Biomolecular Disease Processes, 6 credits
Biomolekylära sjukdomsprocesser, 6 hp
TFKE48
Main field of study
Chemical Biology ChemistryCourse level
Second cycleCourse type
Programme courseExaminer
Peter NilssonDirector of studies or equivalent
Magdalena SvenssonEducation components
Preliminary scheduled hours: 54 hRecommended self-study hours: 106 h
Available for exchange students
YesECV = Elective / Compulsory / Voluntary
| Course offered for | Semester | Period | Timetable module | Language | Campus | ECV | |
|---|---|---|---|---|---|---|---|
| 6CKEB | Chemical Biology, M Sc in Engineering (Protein Science and Technology) | 7 (Autumn 2017) | 2 | 1 | Swedish/English | Linköping, Valla | E |
| 6MPRO | Protein Science, Master's programme (External) | 3 (Autumn 2017) | 2 | 1 | Swedish/English | Linköping, Valla | C |
| 6MPRO | Protein Science, Master's Programme (Internal) | 1 (Autumn 2017) | 2 | 1 | Swedish/English | Linköping, Valla | C |
Main field of study
Chemical Biology, ChemistryCourse level
Second cycleAdvancement level
A1XCourse offered for
- Protein Science, Master's Programme
- Chemical Biology, M Sc in Engineering
- Protein Science, Master's programme
Entry requirements
Note: Admission requirements for non-programme students usually also include admission requirements for the programme and threshold requirements for progression within the programme, or corresponding.
Prerequisites
Protein chemistry. Three years of Chemistry / Chemical biology program or equivalent programIntended learning outcomes
The course aims to provide knowledge of biomolecular processer of common degenerative diseases (Alzheimer´s disease, type II diabetes) and rare diseases (systemic and familial amyloidoses) which collectively are caused by misfolded protein molecules.After the course the student is able to:
- explpain with deep insight of molecular processes concerning protein misfolding.
- explain with deep insight how mutations influence protein conformational changes,
- give avenues for therapeutic strategies against different diseases.
Course content
The course handles the background of a group of human diseases known as the amyloidoses or protein conformational diseases. The links between protein structure, the biophysical and chemical properties of proteins and the link from mutation to conformational change are studied in detail with a number of examples from human diseases.
Proteins studied in detail are: amyloid-beta (Alzheimer’s disease); prion protein (Creutzfeldt Jakob disease); BR12 (familial brittish and danish dementia); immunoglobulin (primary systemic amyloidosis); transthyretin (familial amyloidotic polyneuropathy); high density lipo proteins, amyloid-A (secondary amyloid-A amyloidosis), apoAII; gelsolin (Finnish familial amyloidosis); lysozyme (Inhereted non-neuropathic amyloidois); fibrinogen (inherited nephropathic amyloidosis); beta-2-microglobulin (dialysis related amyloidosis), cystatin-c (heritable cystatin-c amyloid angiopathy), islet amyloid poly peptide (type II diabetes).
The laboratory course contains experimental studies of amyloid fibrils.
Teaching and working methods
The course contains a number of lectures and a seminar series with active participation of the students. A minor laboratory course is also included.
Examination
| LAB1 | Laboratory work | 1 credits | U, G |
| TEN1 | Written examination | 5 credits | U, 3, 4, 5 |
Grades
Four-grade scale, LiU, U, 3, 4, 5Department
Institutionen för fysik, kemi och biologiDirector of Studies or equivalent
Magdalena SvenssonExaminer
Peter NilssonEducation components
Preliminary scheduled hours: 54 hRecommended self-study hours: 106 h
Course literature
Boken: ”Amyloid Proteins. The beta-sheet conformation and disease” vol. 2. Editor Jean D. Sipe (Whiley, VCH), samt vetenskapliga artiklar.| Code | Name | Scope | Grading scale |
|---|---|---|---|
| LAB1 | Laboratory work | 1 credits | U, G |
| TEN1 | Written examination | 5 credits | U, 3, 4, 5 |
Regulations (apply to LiU in its entirety)
The university is a government agency whose operations are regulated by legislation and ordinances, which include the Higher Education Act and the Higher Education Ordinance. In addition to legislation and ordinances, operations are subject to several policy documents. The Linköping University rule book collects currently valid decisions of a regulatory nature taken by the university board, the vice-chancellor and faculty/department boards.
LiU’s rule book for education at first-cycle and second-cycle levels is available at http://styrdokument.liu.se/Regelsamling/Innehall/Utbildning_pa_grund-_och_avancerad_niva.
Course literature is preliminary.
Boken: ”Amyloid Proteins. The beta-sheet conformation and disease” vol. 2. Editor Jean D. Sipe (Whiley, VCH), samt vetenskapliga artiklar.
Note: The course matrix might contain more information in Swedish.
I = Introduce, U = Teach, A = Utilize
| I | U | A | Modules | Comment | ||
|---|---|---|---|---|---|---|
| 1. DISCIPLINARY KNOWLEDGE AND REASONING | ||||||
| 1.1 Knowledge of underlying mathematics and science (G1X level) |
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X
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TEN1
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| 1.2 Fundamental engineering knowledge (G1X level) |
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| 1.3 Further knowledge, methods, and tools in one or several subjects in engineering or natural science (G2X level) |
X
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X
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| 1.4 Advanced knowledge, methods, and tools in one or several subjects in engineering or natural sciences (A1X level) |
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| 1.5 Insight into current research and development work |
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| 2. PERSONAL AND PROFESSIONAL SKILLS AND ATTRIBUTES | ||||||
| 2.1 Analytical reasoning and problem solving |
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| 2.2 Experimentation, investigation, and knowledge discovery |
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X
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LAB1
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| 2.3 System thinking |
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| 2.4 Attitudes, thought, and learning |
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| 2.5 Ethics, equity, and other responsibilities |
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| 3. INTERPERSONAL SKILLS: TEAMWORK AND COMMUNICATION | ||||||
| 3.1 Teamwork |
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X
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| 3.2 Communications |
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X
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| 3.3 Communication in foreign languages |
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X
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| 4. CONCEIVING, DESIGNING, IMPLEMENTING AND OPERATING SYSTEMS IN THE ENTERPRISE, SOCIETAL AND ENVIRONMENTAL CONTEXT | ||||||
| 4.1 External, societal, and environmental context |
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| 4.2 Enterprise and business context |
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| 4.3 Conceiving, system engineering and management |
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| 4.4 Designing |
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| 4.5 Implementing |
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| 4.6 Operating |
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| 5. PLANNING, EXECUTION AND PRESENTATION OF RESEARCH DEVELOPMENT PROJECTS WITH RESPECT TO SCIENTIFIC AND SOCIETAL NEEDS AND REQUIREMENTS | ||||||
| 5.1 Societal conditions, including economic, social, and ecological aspects of sustainable development for knowledge development |
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| 5.2 Economic conditions for knowledge development |
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| 5.3 Identification of needs, structuring and planning of research or development projects |
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| 5.4 Execution of research or development projects |
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| 5.5 Presentation and evaluation of research or development projects |
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X
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