Applied Structural Biology, 6 credits

Tillämpad strukturbiologi, 6 hp

TFKE58

The course is disused.

Main field of study

Chemical Biology

Course level

Second cycle

Course type

Programme course

Examiner

Lars-Göran Mårtensson

Director of studies or equivalent

Magdalena Svensson

Education components

Preliminary scheduled hours: 12 h
Recommended self-study hours: 148 h

Available for exchange students

Yes
ECV = Elective / Compulsory / Voluntary
Course offered for Semester Period Timetable module Language Campus ECV
6CKEB Chemical Biology (Protein Science and Technology) 8 (Spring 2017) 1, 2 3, 4 Swedish/English Linköping, Valla C
6MPRO Protein Science, Master's programme (External) 2 (Spring 2017) 1, 2 3, 4 Swedish/English Linköping, Valla E
6MPRO Protein Science, Master's programme (Internal) 2 (Spring 2017) 1, 2 3, 4 Swedish/English Linköping, Valla E

Main field of study

Chemical Biology

Course level

Second cycle

Advancement level

A1X

Course offered for

  • Protein Science, Master's programme
  • Chemical Biology

Entry requirements

Note: Admission requirements for non-programme students usually also include admission requirements for the programme and threshold requirements for progression within the programme, or corresponding.

Prerequisites

Biochemistry 2, Protein Chemistry, and Protein Engineering, Biostructural technologies

Intended learning outcomes

After completing the course, the student should be able to:

  • understand current methodological approaches for conducting structural studies on proteins and biomolecules using crystallographic and NMR methodologies,
  • apply computer software in general use within the field to generate graphical representations of proteins based on three-dimensional structural data, and use these representations to evaluate structural, biophysical, electrostatical and dynamical properties of proteins
  • understand, evaluate, question and apply results from structural biology by critical reading of scientific literature and deposited structure data (in particular the PDB database)
  • propose, plan and evaluate research- and development projects where methodology from structural biology is applied 

Course content

The lecture part gives in-depth insight in methodologies and approaches regarding structural studies of proteins and biomolecules, and builds on earlier knowledge obtained in the courses Biostructural Technologies and Protein Chemistry. The lecture course as well as application of modern molecular graphics is examined in an individual written examination (UPG1). The remaining part of the course is conducted as three consecutive projects. In the first project (UPG2), articles within key areas in structural biology are distributed to pairs of students by the course leader. The content is presented in an oral presentation using modern molecular graphics to generate illustrations, and in writing as an abstract to the presentation. The oral and written presentation is evaluated in groups. The second project (UPG3) goes deeper into the respective knowledge areas, and the students will here take increased responsibility for choosing the subject and focus in the presentation, which is performed orally in a seminar. The aim of the project is to form the basis for one or more research or development ideas. Selected ideas are then elaborated and presented individually as a Research Proposal in UPG4. 

Teaching and working methods

Teaching is organised in lectures, lessons, seminars, and laboratory tasks (mainly molecular computer graphics). A large part of the course is pursued in project groups of 2-3 students, with regular advisory meetings provided.
The course runs over the entire spring semester.

Examination

UPG4Written report (individual)1.5 creditsU, G
UPG3Oral and Written Presentation1.5 creditsU, G
UPG2Oral and Written Presentation1.5 creditsU, G
UPG1Written assignment (individual)1.5 creditsU, G

Grades are given as ’Pass’ or ’Fail’. For the grade ”Pass”, all examination assignments, reports and presentations must be approved. 

Grades

Two-grade scale, U, G

Department

Institutionen för fysik, kemi och biologi

Director of Studies or equivalent

Magdalena Svensson

Examiner

Lars-Göran Mårtensson

Education components

Preliminary scheduled hours: 12 h
Recommended self-study hours: 148 h

Course literature

Kompendium med utdrag ur referenslitteratur, reviews inom ämnet, samt vetenskapliga artiklar. Excerpts from reference literature, scientific reviews and articles.
Code Name Scope Grading scale
UPG4 Written report (individual) 1.5 credits U, G
UPG3 Oral and Written Presentation 1.5 credits U, G
UPG2 Oral and Written Presentation 1.5 credits U, G
UPG1 Written assignment (individual) 1.5 credits U, G

Grades are given as ’Pass’ or ’Fail’. For the grade ”Pass”, all examination assignments, reports and presentations must be approved. 

Regulations (apply to LiU in its entirety)

The university is a government agency whose operations are regulated by legislation and ordinances, which include the Higher Education Act and the Higher Education Ordinance. In addition to legislation and ordinances, operations are subject to several policy documents. The Linköping University rule book collects currently valid decisions of a regulatory nature taken by the university board, the vice-chancellor and faculty/department boards.

LiU’s rule book for education at first-cycle and second-cycle levels is available at http://styrdokument.liu.se/Regelsamling/Innehall/Utbildning_pa_grund-_och_avancerad_niva. 

Kompendium med utdrag ur referenslitteratur, reviews inom ämnet, samt vetenskapliga artiklar. Excerpts from reference literature, scientific reviews and articles.

Note: The course matrix might contain more information in Swedish.

I = Introduce, U = Teach, A = Utilize
I U A Modules Comment
1. DISCIPLINARY KNOWLEDGE AND REASONING
1.1 Knowledge of underlying mathematics and science (G1X level)

                            
1.2 Fundamental engineering knowledge (G1X level)

                            
1.3 Further knowledge, methods, and tools in one or several subjects in engineering or natural science (G2X level)

                            
1.4 Advanced knowledge, methods, and tools in one or several subjects in engineering or natural sciences (A1X level)

                            
1.5 Insight into current research and development work

                            
2. PERSONAL AND PROFESSIONAL SKILLS AND ATTRIBUTES
2.1 Analytical reasoning and problem solving

                            
2.2 Experimentation, investigation, and knowledge discovery

                            
2.3 System thinking

                            
2.4 Attitudes, thought, and learning

                            
2.5 Ethics, equity, and other responsibilities

                            
3. INTERPERSONAL SKILLS: TEAMWORK AND COMMUNICATION
3.1 Teamwork

                            
3.2 Communications

                            
3.3 Communication in foreign languages

                            
4. CONCEIVING, DESIGNING, IMPLEMENTING AND OPERATING SYSTEMS IN THE ENTERPRISE, SOCIETAL AND ENVIRONMENTAL CONTEXT
4.1 External, societal, and environmental context

                            
4.2 Enterprise and business context

                            
4.3 Conceiving, system engineering and management

                            
4.4 Designing

                            
4.5 Implementing

                            
4.6 Operating

                            
5. PLANNING, EXECUTION AND PRESENTATION OF RESEARCH DEVELOPMENT PROJECTS WITH RESPECT TO SCIENTIFIC AND SOCIETAL NEEDS AND REQUIREMENTS
5.1 Societal conditions, including economic, social, and ecological aspects of sustainable development for knowledge development

                            
5.2 Economic conditions for knowledge development

                            
5.3 Identification of needs, structuring and planning of research or development projects

                            
5.4 Execution of research or development projects

                            
5.5 Presentation and evaluation of research or development projects

                            

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