Introduction to Biosensor Technology, 6 credits

Introduktion till biosensorteknik, 6 hp

TFYA62

Main field of study

Applied Physics Physics Biomedical Engineering

Course level

First cycle

Course type

Programme course

Examiner

Edwin Jager

Course coordinator

Edwin Jager

Director of studies or equivalent

Magnus Boman

Education components

Preliminary scheduled hours: 80 h
Recommended self-study hours: 80 h

Available for exchange students

Yes
ECV = Elective / Compulsory / Voluntary
Course offered for Semester Period Timetable module Language Campus ECV
6CMED Biomedical Engineering, Master of Science in Engineering 4 (Spring 2021) 1 4 English Linköping, Valla C
6CIEI Industrial Engineering and Management - International, M Sc in Engineering - Chinese 8 (Spring 2021) 1 4 English Linköping, Valla E
6CIEI Industrial Engineering and Management - International, M Sc in Engineering - French 8 (Spring 2021) 1 4 English Linköping, Valla E
6CIEI Industrial Engineering and Management - International, M Sc in Engineering - German 8 (Spring 2021) 1 4 English Linköping, Valla E
6CIEI Industrial Engineering and Management - International, M Sc in Engineering - Japanese 8 (Spring 2021) 1 4 English Linköping, Valla E
6CIEI Industrial Engineering and Management - International, M Sc in Engineering - Spanish 8 (Spring 2021) 1 4 English Linköping, Valla E
6CIII Industrial Engineering and Management, M Sc in Engineering 8 (Spring 2021) 1 4 English Linköping, Valla E

Main field of study

Applied Physics, Physics, Biomedical Engineering

Course level

First cycle

Advancement level

G2X

Course offered for

  • Master of Science in Biomedical Engineering
  • Industrial Engineering and Management - International, M Sc in Engineering
  • Industrial Engineering and Management, M Sc in Engineering

Prerequisites

Biochemistry and Cell Biology, Materials for Biomedical Engineering

Intended learning outcomes

The purpose of the course is to provide a broad introduction to biosensor technology including:

  • Working principle of the biosensors,
  • Biosensors classification,
  • Use of biological macromolecules as sensing elements,
  • Presenting how engineering and biology can be used to perform diagnosis.


After finishing the course the student should be able to:

  • Describe the working principles of biosensors,
  • Explain the nature and mechanism of the biorecognition event,
  • Describe and explain the main transduction techniques used in biosensor technology,
  • Evaluate a sensor based on standard performance criteria and appropriateness for a given application.

 

Course content

 

  • Introduction to biosensors,
  • Biorecognition elements,
  • Transduction principle,
  • Surface functionalization in biosensors,
  • Surface plasmon resonance biosensors (Biacore),
  • Catalytic biosensors (glucosensor),
  • Antibodies based biosensors,
  • DNA based biosensors,
  • Microsystem working principles and their application to biosensor technology,
  • Analytical parameters for sensor evaluation.

     

Teaching and working methods

The course comprises lectures, tutorial sessions, laboratory exersises and group work including a seminar.

Laboratory exercises and demonstrations will be held at IFM. In conjuction with each laboratory exercise/demonstration, the students will have to write a lab report or answer a questionary.

Group work
The students will be divided in groups and each team will be assigned a research article to study. Each team will present this artical in front of the class during the seminar. In addition, each student will have to write an individual assay to demonstrate their understanding of the assigned article and relate it to the course contents.

Examination

UPG1Group work of exercise2.5 creditsU, G
LAB1Laboratory work and reports1 creditsU, G
TEN1Written tests2.5 creditsU, 3, 4, 5

Grading will be based on final written test, laboratory reports and group work exercise. When all assignments are approved the final grade will be set by the written examination grade.

Grades

Four-grade scale, LiU, U, 3, 4, 5

Other information

About teaching and examination language

The teaching language is presented in the Overview tab for each course. The examination language relates to the teaching language as follows: 

  • If teaching language is Swedish, the course as a whole or in large parts, is taught in Swedish. Please note that although teaching language is Swedish, parts of the course could be given in English. Examination language is Swedish. 
  • If teaching language is Swedish/English, the course as a whole will be taught in English if students without prior knowledge of the Swedish language participate. Examination language is Swedish or English (depending on teaching language). 
  • If teaching language is English, the course as a whole is taught in English. Examination language is English. 

Other

The course is conducted in a manner where both men's and women's experience and knowledge are made visible and developed. 

The planning and implementation of a course should correspond to the course syllabus. The course evaluation should therefore be conducted with the course syllabus as a starting point.  

Department

Institutionen för fysik, kemi och biologi

Director of Studies or equivalent

Magnus Boman

Examiner

Edwin Jager

Course website and other links

LISAM

Education components

Preliminary scheduled hours: 80 h
Recommended self-study hours: 80 h

Course literature

Books

  • Brian R. Eggins, (2002) Chemical sensors and biosensors Wiley
  • Cooper, Jonathan M.; Cass, Anthony E. G., (2004) Biosensors. The Practical Approach Series Volume 268
  • Gennady Evtugyn, (2014) Biosensors: Essentials Springer
    ISBN: 977-3-642-40240-1
  • Robert S. Marks, Christopher R. Lowe, David C. Cullen, Howard H. Weetall, Isao Karube, (2007) Handbook of Biosensors and Biochips e-book Wiley

Websites

Other

  • Lecture notes - pdf copies of power point slides and other material handed out by the respective lecturer
Code Name Scope Grading scale
UPG1 Group work of exercise 2.5 credits U, G
LAB1 Laboratory work and reports 1 credits U, G
TEN1 Written tests 2.5 credits U, 3, 4, 5

Grading will be based on final written test, laboratory reports and group work exercise. When all assignments are approved the final grade will be set by the written examination grade.

Course syllabus

A syllabus must be established for each course. The syllabus specifies the aim and contents of the course, and the prior knowledge that a student must have in order to be able to benefit from the course.

Timetabling

Courses are timetabled after a decision has been made for this course concerning its assignment to a timetable module. 

Interrupting a course

The vice-chancellor’s decision concerning regulations for registration, deregistration and reporting results (Dnr LiU-2015-01241) states that interruptions in study are to be recorded in Ladok. Thus, all students who do not participate in a course for which they have registered must record the interruption, such that the registration on the course can be removed. Deregistration from a course is carried out using a web-based form: https://www.lith.liu.se/for-studenter/kurskomplettering?l=en. 

Cancelled courses

Courses with few participants (fewer than 10) may be cancelled or organised in a manner that differs from that stated in the course syllabus. The Dean is to deliberate and decide whether a course is to be cancelled or changed from the course syllabus. 

Guidelines relating to examinations and examiners 

For details, see Guidelines for education and examination for first-cycle and second-cycle education at Linköping University, Dnr LiU-2019-00920 (http://styrdokument.liu.se/Regelsamling/VisaBeslut/917592).

An examiner must be employed as a teacher at LiU according to the LiU Regulations for Appointments, Dnr LiU-2017-03931 (https://styrdokument.liu.se/Regelsamling/VisaBeslut/622784). For courses in second-cycle, the following teachers can be appointed as examiner: Professor (including Adjunct and Visiting Professor), Associate Professor (including Adjunct), Senior Lecturer (including Adjunct and Visiting Senior Lecturer), Research Fellow, or Postdoc. For courses in first-cycle, Assistant Lecturer (including Adjunct and Visiting Assistant Lecturer) can also be appointed as examiner in addition to those listed for second-cycle courses. In exceptional cases, a Part-time Lecturer can also be appointed as an examiner at both first- and second cycle, see Delegation of authority for the Board of Faculty of Science and Engineering.

Forms of examination

Principles for examination

Written and oral examinations and digital and computer-based examinations are held at least three times a year: once immediately after the end of the course, once in August, and once (usually) in one of the re-examination periods. Examinations held at other times are to follow a decision of the board of studies.

Principles for examination scheduling for courses that follow the study periods:

  • courses given in VT1 are examined for the first time in March, with re-examination in June and August
  • courses given in VT2 are examined for the first time in May, with re-examination in August and October
  • courses given in HT1 are examined for the first time in October, with re-examination in January and August
  • courses given in HT2 are examined for the first time in January, with re-examination in March and in August.

The examination schedule is based on the structure of timetable modules, but there may be deviations from this, mainly in the case of courses that are studied and examined for several programmes and in lower grades (i.e. 1 and 2). 

Examinations for courses that the board of studies has decided are to be held in alternate years are held three times during the school year in which the course is given according to the principles stated above.

Examinations for courses that are cancelled or rescheduled such that they are not given in one or several years are held three times during the year that immediately follows the course, with examination scheduling that corresponds to the scheduling that was in force before the course was cancelled or rescheduled.

When a course is given for the last time, the regular examination and two re-examinations will be offered. Thereafter, examinations are phased out by offering three examinations during the following academic year at the same times as the examinations in any substitute course. If there is no substitute course, three examinations will be offered during re-examination periods during the following academic year. Other examination times are decided by the board of studies. In all cases above, the examination is also offered one more time during the academic year after the following, unless the board of studies decides otherwise.

If a course is given during several periods of the year (for programmes, or on different occasions for different programmes) the board or boards of studies determine together the scheduling and frequency of re-examination occasions.

Retakes of other forms of examination

Regulations concerning retakes of other forms of examination than written examinations and digital and computer-based examinations are given in the LiU guidelines for examinations and examiners, http://styrdokument.liu.se/Regelsamling/VisaBeslut/917592.

Registration for examination

Until January 31 2021, the following applies according to previous guidelines: In order to take an written, digital or computer-based examination student must register in advance at the Student Portal during the registration period, which opens 30 days before the date of the examination and closes 10 days before it. Candidates are informed of the location of the examination by email, four days in advance. Students who have not registered for an examination run the risk of being refused admittance to the examination, if space is not available.

From February 1 2021, new guidelines applies for registration for written, digital or computer-based examination, Dnr LiU-2020-02033 (https://styrdokument.liu.se/Regelsamling/VisaBeslut/622682).

Symbols used in the examination registration system:

  ** denotes that the examination is being given for the penultimate time.

  * denotes that the examination is being given for the last time.

Code of conduct for students during examinations

Details are given in a decision in the university’s rule book: http://styrdokument.liu.se/Regelsamling/VisaBeslut/622682.

Retakes for higher grade

Students at the Institute of Technology at LiU have the right to retake written examinations and digital and computer-based examinations in an attempt to achieve a higher grade. This is valid for all examination components with code “TEN”, “DIT” and "DAT". The same right may not be exercised for other examination components, unless otherwise specified in the course syllabus.

A retake is not possible on courses that are included in an issued degree diploma. 

Grades

The grades that are preferably to be used are Fail (U), Pass (3), Pass not without distinction (4) and Pass with distinction (5). 

  • Grades U, 3, 4, 5 are to be awarded for courses that have written or digital examinations.
  • Grades Fail (U) and Pass (G) may be awarded for courses with a large degree of practical components such as laboratory work, project work and group work.
  • Grades Fail (U) and Pass (G) are to be used for degree projects and other independent work.

Examination components

The following examination components and associated module codes are used at the Faculty of Science and Engineering:

  • Grades U, 3, 4, 5 are to be awarded for written examinations (TEN) and digital examinations (DIT).
  • Examination components for which the grades Fail (U) and Pass (G) may be awarded are laboratory work (LAB), project work (PRA), preparatory written examination (KTR), digital preparatory written examination (DIK), oral examination (MUN), computer-based examination (DAT), home assignment (HEM), and assignment (UPG).
  • Students receive grades either Fail (U) or Pass (G) for other examination components in which the examination criteria are satisfied principally through active attendance such as tutorial group (BAS) or examination item (MOM).
  • Grades Fail (U) and Pass (G) are to be used for the examination components Opposition (OPPO) and Attendance at thesis presentation (AUSK) (i.e. part of the degree project).

In general, the following applies:

  • Mandatory course components must be scored and given a module code.
  • Examination components that are not scored, cannot be mandatory. Hence, it is voluntary to participate in these examinations, and the voluntariness must be clearly stated. Additionally, if there are any associated conditions to the examination component, these must be clearly stated as well.
  • For courses with more than one examination component with grades U,3,4,5, it shall be clearly stated how the final grade is weighted.

For mandatory components, the following applies: If special circumstances prevail, and if it is possible with consideration of the nature of the compulsory component, the examiner may decide to replace the compulsory component with another equivalent component. (In accordance with the LiU Guidelines for education and examination for first-cycle and second-cycle education at Linköping University, http://styrdokument.liu.se/Regelsamling/VisaBeslut/917592). 

For written examinations, the following applies: If the LiU coordinator for students with disabilities has granted a student the right to an adapted examination for a written examination in an examination hall, the student has the right to it. If the coordinator has instead recommended for the student an adapted examination or alternative form of examination, the examiner may grant this if the examiner assesses that it is possible, based on consideration of the course objectives. (In accordance with the LiU Guidelines for education and examination for first-cycle and second-cycle education at Linköping University, http://styrdokument.liu.se/Regelsamling/VisaBeslut/917592).

Reporting of examination results

The examination results for a student are reported at the relevant department.

Plagiarism

For examinations that involve the writing of reports, in cases in which it can be assumed that the student has had access to other sources (such as during project work, writing essays, etc.), the material submitted must be prepared in accordance with principles for acceptable practice when referring to sources (references or quotations for which the source is specified) when the text, images, ideas, data, etc. of other people are used. It is also to be made clear whether the author has reused his or her own text, images, ideas, data, etc. from previous examinations, such as degree projects, project reports, etc. (this is sometimes known as “self-plagiarism”).

A failure to specify such sources may be regarded as attempted deception during examination.

Attempts to cheat

In the event of a suspected attempt by a student to cheat during an examination, or when study performance is to be assessed as specified in Chapter 10 of the Higher Education Ordinance, the examiner is to report this to the disciplinary board of the university. Possible consequences for the student are suspension from study and a formal warning. More information is available at https://www.student.liu.se/studenttjanster/lagar-regler-rattigheter?l=en.

Regulations (apply to LiU in its entirety)

The university is a government agency whose operations are regulated by legislation and ordinances, which include the Higher Education Act and the Higher Education Ordinance. In addition to legislation and ordinances, operations are subject to several policy documents. The Linköping University rule book collects currently valid decisions of a regulatory nature taken by the university board, the vice-chancellor and faculty/department boards.

LiU’s rule book for education at first-cycle and second-cycle levels is available at http://styrdokument.liu.se/Regelsamling/Innehall/Utbildning_pa_grund-_och_avancerad_niva. 

Books

Brian R. Eggins, (2002) Chemical sensors and biosensors Wiley
Cooper, Jonathan M.; Cass, Anthony E. G., (2004) Biosensors. The Practical Approach Series Volume 268
Gennady Evtugyn, (2014) Biosensors: Essentials Springer

ISBN: 977-3-642-40240-1

Robert S. Marks, Christopher R. Lowe, David C. Cullen, Howard H. Weetall, Isao Karube, (2007) Handbook of Biosensors and Biochips e-book Wiley

Websites

Other

Lecture notes - pdf copies of power point slides and other material handed out by the respective lecturer

Note: The course matrix might contain more information in Swedish.

I = Introduce, U = Teach, A = Utilize
I U A Modules Comment
1. DISCIPLINARY KNOWLEDGE AND REASONING
1.1 Knowledge of underlying mathematics and science (G1X level)
X
LAB1
TEN1
UPG1
Fundamental knowledge on biosensors and biointeractions is taught.
1.2 Fundamental engineering knowledge (G1X level)
X
LAB1
TEN1
UPG1
Fundamental knowledge on biosensors, sensor measurement science, and biointeractions is taught.
1.3 Further knowledge, methods, and tools in one or several subjects in engineering or natural science (G2X level)
X
LAB1
TEN1
UPG1
In depth knowledge on specific biosensor technieques is taught.
1.4 Advanced knowledge, methods, and tools in one or several subjects in engineering or natural sciences (A1X level)
X
LAB1
TEN1
UPG1
Practical and theoretical measurement methods and instruments are taught.
1.5 Insight into current research and development work
X
UPG1
Guest lectures and exemples of ongoing research are given. In the group exercise a research paper is studied.
2. PERSONAL AND PROFESSIONAL SKILLS AND ATTRIBUTES
2.1 Analytical reasoning and problem solving
X
X
LAB1
UPG1
Laboratory exercises and a group work on a small project
2.2 Experimentation, investigation, and knowledge discovery
X
X
LAB1
UPG1
In the laboratory exercise the students will have to construct a biosensor, validate it and use it in a chosen application.
2.3 System thinking
X
X
LAB1
In the laboratory exercise the students will have to construct a biosensor, validate it and use it in a chosen application.
2.4 Attitudes, thought, and learning

                            
2.5 Ethics, equity, and other responsibilities
X
Ethical implications of biosensors will be discussed during the lectures.
3. INTERPERSONAL SKILLS: TEAMWORK AND COMMUNICATION
3.1 Teamwork
X
LAB1
UPG1
Laboratory exercises and a group work on a small project
3.2 Communications
X
LAB1
UPG1
Laboratory reports. Project essay and oral presentation of the project work in front of the whole class.
3.3 Communication in foreign languages
X
LAB1
TEN1
UPG1
The course is completely taught in English. Reports, presentations, and exam are all in English.
4. CONCEIVING, DESIGNING, IMPLEMENTING AND OPERATING SYSTEMS IN THE ENTERPRISE, SOCIETAL AND ENVIRONMENTAL CONTEXT
4.1 External, societal, and environmental context
X
X
(Ethical) Aspects of biosensors are discussed
4.2 Enterprise and business context
X
Commercialisiation of biosensors is discussed and exemples thereof are given.
4.3 Conceiving, system engineering and management
X
X
LAB1
TEN1
Applications of biosensors are discussed. 
Construction, validation and application of biosensors is taught including building a simple biosensor in a laboratory exercise.
4.4 Designing
X
X
LAB1
TEN1
Construction, validation and application of biosensors is taught including building a simple biosensor in a laboratory exercise.
4.5 Implementing
X
X
LAB1
Construction, validation and application of biosensors is taught including building a simple biosensor in a laboratory exercise.
4.6 Operating
X
X
LAB1
Construction, validation and application of biosensors is taught including building a simple biosensor in a laboratory exercise.
5. PLANNING, EXECUTION AND PRESENTATION OF RESEARCH DEVELOPMENT PROJECTS WITH RESPECT TO SCIENTIFIC AND SOCIETAL NEEDS AND REQUIREMENTS
5.1 Societal conditions, including economic, social, and ecological aspects of sustainable development for knowledge development
X
X
(Ethical) Aspects of biosensors are discussed
5.2 Economic conditions for knowledge development
X
Commercialisiation of biosensors is discussed and exemples thereof are given.
5.3 Identification of needs, structuring and planning of research or development projects
X
X
LAB1
TEN1
Applications of biosensors are discussed. 
Construction, validation and application of biosensors is taught including building a simple biosensor in a laboratory exercise.
5.4 Execution of research or development projects
X
X
LAB1
TEN1
Construction, validation and application of biosensors is taught including building a simple biosensor in a laboratory exercise.
5.5 Presentation and evaluation of research or development projects
X
X
LAB1
UPG1
Lab reports will be written and the group work will be presented in front of the class and an individual essay will be written.

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