Genome Analysis, 6 credits

Genome Analysis, 6 hp

TVCB12

The course is disused.

Main field of study

Engineering Biology

Course level

Second cycle

Course type

Programme course

Examiner

Peter Söderkvist

Director of studies or equivalent

Kajsa Holmgren Peterson

Education components

Preliminary scheduled hours: 51 h
Recommended self-study hours: 109 h

Available for exchange students

Yes
ECV = Elective / Compulsory / Voluntary
Course offered for Semester Period Timetable module Language Campus ECV
6CKEB Chemical Biology, M Sc in Engineering (Industrial Biotechnology and Production) 7 (Autumn 2017) 1 4 English Linköping C
6CTBI Engineering Biology, M Sc in Engineering (Industrial biotechnology and production) 7 (Autumn 2017) 1 4 English Linköping C

Main field of study

Engineering Biology

Course level

Second cycle

Advancement level

A1X

Course offered for

  • Chemical Biology, M Sc in Engineering
  • Engineering Biology, M Sc in Engineering

Entry requirements

Note: Admission requirements for non-programme students usually also include admission requirements for the programme and threshold requirements for progression within the programme, or corresponding.

Prerequisites

Gene Technology

Intended learning outcomes

In this course the student will acquire advanced theoretical and methodological knowledge in genome analysis as well as molecular mechanisms involved in monogenic and polygenic traits and diseases. In a project laboratory work the student study the strategies for disease gene identification with advanced genetic laboratory methods, bioinformatics and interpretation of results. The student will also obtain knowledge in molecular epidemiology and how genetic variation in populations influence genetic predisposition for disease. By the end of the course the student will be able to:

Knowledge and understanding
- Comprehend and integrate the knowledge on molecular mechanisms involved in monogenic and polygenic traits to understand the genetic basis of diseases
- Describe the interplay between genetic and environmental factors
- Explain how concepts of genetic variation in populations are affecting evolution and population genetics
- Identify strategies and explain the theoretical basis of molecular genetics methodology to be able to identify disease genes

Competence and skills
- Demonstrate how calculation of genetic association and risk is performed
- Apply computer-based methods to be able to identify disease genes
- Practically perform and explain selected molecular genetics methodology for gene identification

Judgement and approach
- Interpret experimental results and evaluate genetic association studies and risk calculations
- Present, evaluate and communicate pros and cons of molecular genetics methods
- Summarise and assess scientific literature within medical genetics

Course content

Molecular mechanisms involved in monogenic and polygenic traits and diseases
Disease gene identification
How environmental factors influence the genome and affects expression
Genetic variation in populations and its influence on genetic predisposition, including molecular/genetic epidemiology
Calculation of allele frequencies, associations and risk
Principles of major molecular genetic laboratory methods and interpretation of results, hands-on knowledge of selected methodology
Seminars on selected scientific papers

Teaching and working methods

The course applies student-centered learning among which Problem Based Learning (PBL) is one pedagogical philosophy and method. The PBL design of the course emphasises the student´s development of free, self-supporting, lifelong learning as an instrument for critical inquiry. The students are also encouraged to take responsibility for her/his own learning, and to seek and evaluate information and knowledge and to train co-operation and a flexible attitude to different views and ideas. The educational methods include lectures, tutorial groups, seminars, demonstrations and laboratory work.

Examination

UPG2Completed assignments1 creditsU, G
UPG1Active participation in seminars1 creditsU, G
BAS1Active participation in tutorial groups1 creditsU, G
TEN1Written examination3 creditsU, 3, 4, 5
Assignments, presentations, written examination in English.

Grades

Four-grade scale, LiU, U, 3, 4, 5

Department

Institutionen för klinisk och experimentell medicin

Director of Studies or equivalent

Kajsa Holmgren Peterson

Examiner

Peter Söderkvist

Education components

Preliminary scheduled hours: 51 h
Recommended self-study hours: 109 h

Course literature

Additional literature

Books

  • Strachan, Tom & Read, Andrew P, (2010) Human Molecular Genetics 4th ed

Articles

Code Name Scope Grading scale
UPG2 Completed assignments 1 credits U, G
UPG1 Active participation in seminars 1 credits U, G
BAS1 Active participation in tutorial groups 1 credits U, G
TEN1 Written examination 3 credits U, 3, 4, 5
Assignments, presentations, written examination in English.

Regulations (apply to LiU in its entirety)

The university is a government agency whose operations are regulated by legislation and ordinances, which include the Higher Education Act and the Higher Education Ordinance. In addition to legislation and ordinances, operations are subject to several policy documents. The Linköping University rule book collects currently valid decisions of a regulatory nature taken by the university board, the vice-chancellor and faculty/department boards.

LiU’s rule book for education at first-cycle and second-cycle levels is available at http://styrdokument.liu.se/Regelsamling/Innehall/Utbildning_pa_grund-_och_avancerad_niva. 

Additional literature

Books

Strachan, Tom & Read, Andrew P, (2010) Human Molecular Genetics 4th ed

Articles

Note: The course matrix might contain more information in Swedish.

I = Introduce, U = Teach, A = Utilize
I U A Modules Comment
1. DISCIPLINARY KNOWLEDGE AND REASONING
1.1 Knowledge of underlying mathematics and science (G1X level)
X
X
BAS1
TEN1

                            
1.2 Fundamental engineering knowledge (G1X level)
X
X
BAS1
TEN1
UPG1
UPG2

                            
1.3 Further knowledge, methods, and tools in one or several subjects in engineering or natural science (G2X level)
X
X
BAS1
TEN1

                            
1.4 Advanced knowledge, methods, and tools in one or several subjects in engineering or natural sciences (A1X level)

                            
1.5 Insight into current research and development work

                            
2. PERSONAL AND PROFESSIONAL SKILLS AND ATTRIBUTES
2.1 Analytical reasoning and problem solving
X
X
BAS1
TEN1
UPG1

                            
2.2 Experimentation, investigation, and knowledge discovery
X
X
BAS1
TEN1
UPG2

                            
2.3 System thinking

                            
2.4 Attitudes, thought, and learning
X
X
BAS1
UPG2

                            
2.5 Ethics, equity, and other responsibilities

                            
3. INTERPERSONAL SKILLS: TEAMWORK AND COMMUNICATION
3.1 Teamwork
X
BAS1
UPG1
UPG2

                            
3.2 Communications
X
BAS1
UPG1
UPG2

                            
3.3 Communication in foreign languages
X

                            
4. CONCEIVING, DESIGNING, IMPLEMENTING AND OPERATING SYSTEMS IN THE ENTERPRISE, SOCIETAL AND ENVIRONMENTAL CONTEXT
4.1 External, societal, and environmental context

                            
4.2 Enterprise and business context

                            
4.3 Conceiving, system engineering and management

                            
4.4 Designing

                            
4.5 Implementing

                            
4.6 Operating

                            
5. PLANNING, EXECUTION AND PRESENTATION OF RESEARCH DEVELOPMENT PROJECTS WITH RESPECT TO SCIENTIFIC AND SOCIETAL NEEDS AND REQUIREMENTS
5.1 Societal conditions, including economic, social, and ecological aspects of sustainable development for knowledge development

                            
5.2 Economic conditions for knowledge development

                            
5.3 Identification of needs, structuring and planning of research or development projects

                            
5.4 Execution of research or development projects

                            
5.5 Presentation and evaluation of research or development projects
X
UPG1
UPG2

                            

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