Supramolecular Chemistry, 6 credits

Supramolekylär kemi, 6 hp

TFYA30

Main field of study

Engineering Biology

Course level

Second cycle

Course type

Programme course

Examiner

Daniel Aili

Director of studies or equivalent

Magnus Boman

Education components

Preliminary scheduled hours: 38 h
Recommended self-study hours: 122 h

Available for exchange students

Yes
ECV = Elective / Compulsory / Voluntary
Course offered for Semester Period Timetable module Language Campus ECV
6CMED 9 (Autumn 2017) 2 1 Swedish/English Linköping E
6CMED (Biomedical Materials) 9 (Autumn 2017) 2 1 Swedish/English Linköping C
6CKEB Chemical Biology (Protein Science and Technology) 9 (Autumn 2017) 2 1 Swedish/English Linköping E
6CTBI Engineering Biology, M Sc in Engineering (Devices and Materials in Biomedicine) 7 (Autumn 2017) 2 1 Swedish/English Linköping C

Main field of study

Engineering Biology

Course level

Second cycle

Advancement level

A1X

Course offered for

  • Engineering Biology, M Sc in Engineering
  • Chemical Biology

Entry requirements

Note: Admission requirements for non-programme students usually also include admission requirements for the programme and threshold requirements for progression within the programme, or corresponding.

Prerequisites

Basic knowledge about organic chemistry, biochemistry, thermodynamics, surface chemistry and quantum mechanics.

Intended learning outcomes

Supramolecular chemistry is a rapidly growing field at the boundary between several physical and chemical disciplines, and this course brings together aspects of those which are of relevance to supramolecular chemistry. The students will be introduced to the subject background, acquire in-depth knowledge about supramolecular building blocks, structures and methods, and learn about applications, with some emphasis on life sciences and its technologies. This implies that after the course, the students shall

  • be able to account for fundamental concepts, methods and theories within supramolecular chemistry.
  • be able to understand and account for current problems and research in the field.
  • have special competence about the importance of supramolecular association within the life sciences and life science technologies.
  • have practical experience from analytical methods for characterization of supramolecular systems.
  • be able to interpret, analyse och evaluate experimental data of supramolecular interactions.

Course content

Introduction and background to the subject of supramolecular chemistry. Introduction to bottom-up methods: intermolecular forces and non-covalent interactions, inter- and intramolecular self-association, self-organization, supramolecular topology. Molecular recognition and complementarity, natural and synthetic host-guest pairs, lock-and-key versus induced-fit models. Chelators, koordination chemistry, cooperativity, multivalency. Organic and biomolecular building blocks. Biological membranes: structure, phase behaviour, domain formation, model systems, protein-membrane interaction, evolutionary aspects. Proteins and peptides: folding, synthesis strategies, labeling, immobilization, natural and synthetic receptors. Surface modification: 2- and 3-dimensional modification, monolayers versus hydrogels. Carbohydrates: biological and biomimetic recognition, coupling chemistry, receptors, molecular design and synthesis.
A selection of application areas, such as sensor technology, membrane biophysics, proteomics, biomaterials, drug delivery, molecular devices, nanotechnology.

Teaching and working methods

Lectures, laboratory exercises and a project work in small groups. External lecturers will be invited to present current applications or reserch problems.

Examination

LAB1Laboratory Work1.5 creditsU, G
PRA5Project work, written and oral presentation2 creditsU, 3, 4, 5
UPG2Literature assignment, written presentation2.5 creditsU, 3, 4, 5

The final grade is a weighted average of the grades on UPG2 and PRA5. 

Grades

Four-grade scale, LiU, U, 3, 4, 5

Department

Institutionen för fysik, kemi och biologi

Director of Studies or equivalent

Magnus Boman

Examiner

Daniel Aili

Education components

Preliminary scheduled hours: 38 h
Recommended self-study hours: 122 h

Course literature

Additional literature

Books

  • Jonathan W Steed, Jerry L Atwood, (2009) Supramolecular Chemistry 2nd Ed

Articles

Code Name Scope Grading scale
LAB1 Laboratory Work 1.5 credits U, G
PRA5 Project work, written and oral presentation 2 credits U, 3, 4, 5
UPG2 Literature assignment, written presentation 2.5 credits U, 3, 4, 5

The final grade is a weighted average of the grades on UPG2 and PRA5. 

Regulations (apply to LiU in its entirety)

The university is a government agency whose operations are regulated by legislation and ordinances, which include the Higher Education Act and the Higher Education Ordinance. In addition to legislation and ordinances, operations are subject to several policy documents. The Linköping University rule book collects currently valid decisions of a regulatory nature taken by the university board, the vice-chancellor and faculty/department boards.

LiU’s rule book for education at first-cycle and second-cycle levels is available at http://styrdokument.liu.se/Regelsamling/Innehall/Utbildning_pa_grund-_och_avancerad_niva. 

Additional literature

Books

Jonathan W Steed, Jerry L Atwood, (2009) Supramolecular Chemistry 2nd Ed

Articles

Note: The course matrix might contain more information in Swedish.

I = Introduce, U = Teach, A = Utilize
I U A Modules Comment
1. DISCIPLINARY KNOWLEDGE AND REASONING
1.1 Knowledge of underlying mathematics and science (G1X level)
X
X
PRA5
UPG2

                            
1.2 Fundamental engineering knowledge (G1X level)
X
PRA5
UPG2

                            
1.3 Further knowledge, methods, and tools in one or several subjects in engineering or natural science (G2X level)
X
X
X
PRA5
UPG2

                            
1.4 Advanced knowledge, methods, and tools in one or several subjects in engineering or natural sciences (A1X level)

                            
1.5 Insight into current research and development work

                            
2. PERSONAL AND PROFESSIONAL SKILLS AND ATTRIBUTES
2.1 Analytical reasoning and problem solving
X
PRA5
UPG2

                            
2.2 Experimentation, investigation, and knowledge discovery
X
LAB1
PRA5

                            
2.3 System thinking
X
PRA5

                            
2.4 Attitudes, thought, and learning
X
PRA5

                            
2.5 Ethics, equity, and other responsibilities
X
PRA5

                            
3. INTERPERSONAL SKILLS: TEAMWORK AND COMMUNICATION
3.1 Teamwork
X
PRA5

                            
3.2 Communications
X
PRA5

                            
3.3 Communication in foreign languages
X
PRA5
UPG2

                            
4. CONCEIVING, DESIGNING, IMPLEMENTING AND OPERATING SYSTEMS IN THE ENTERPRISE, SOCIETAL AND ENVIRONMENTAL CONTEXT
4.1 External, societal, and environmental context
X
PRA5

                            
4.2 Enterprise and business context

                            
4.3 Conceiving, system engineering and management
X
PRA5

                            
4.4 Designing

                            
4.5 Implementing

                            
4.6 Operating

                            
5. PLANNING, EXECUTION AND PRESENTATION OF RESEARCH DEVELOPMENT PROJECTS WITH RESPECT TO SCIENTIFIC AND SOCIETAL NEEDS AND REQUIREMENTS
5.1 Societal conditions, including economic, social, and ecological aspects of sustainable development for knowledge development

                            
5.2 Economic conditions for knowledge development

                            
5.3 Identification of needs, structuring and planning of research or development projects
X
X
LAB1
PRA5

                            
5.4 Execution of research or development projects
X
X
LAB1
PRA5

                            
5.5 Presentation and evaluation of research or development projects
X
X
LAB1
PRA5

                            

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